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Match the description with the type of receptor model. -intracellular mediator


A) nuclear receptor model
B) membrane-bound receptor model

C) A) and B)
D) undefined

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The length of time needed to eliminate half of a dose of a hormone is called its _______ ________.

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Which chemical class of hormone is more likely to need a binding protein for transport in the blood?


A) water-soluble
B) amino acid derivative
C) protein
D) lipid-soluble

E) All of the above
F) A) and D)

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Lipid-soluble hormones can be more easily excreted once they have water-soluble molecules added to their structure in a process called


A) saponification.
B) amplitude-modulation.
C) conjugation.
D) protein-binding.

E) A) and C)
F) B) and D)

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In general,the response of target cells to endocrine stimulation is _______ than their response to nervous stimulation.


A) faster and briefer
B) slower and more prolonged
C) more accurate
D) more restricted to a small area of the body
E) more intense

F) C) and E)
G) C) and D)

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Match the description with the type of receptor model. -generally observe a latent period


A) nuclear receptor model
B) membrane-bound receptor model

C) A) and B)
D) undefined

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Arrange the following events in proper sequence: (1) The activating hormone interacts with a membrane-bound receptor. (2) Cyclic AMP causes the cell to carry out a function characteristic for that specific hormone. (3) Adenylyl cyclase catalyzes the transformation of ATP to cyclic AMP. (4) Adenylyl cyclase is activated.


A) 1,2,3,4
B) 1,4,3,2
C) 3,4,2,1
D) 1,3,2,4
E) 1,3,4,2

F) None of the above
G) A) and E)

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The half-life of a hormone allows one to determine


A) the rate of hormone secretion.
B) the identity of a hormone.
C) the rate at which hormones are eliminated from the body.
D) the rate of action of a hormone.
E) the rate of travel through the blood to a target.

F) A) and B)
G) C) and D)

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Cortisol,a lipid-soluble hormone is released into the blood.Predict what cortisol might do.


A) can dissolve in the blood as free hormone
B) needs fenestrated capillaries to move out of the blood stream
C) readily diffuses through capillary wall
D) rapidly degraded by proteases in the bloodstream
E) may have carbohydrates attached to give a longer half-life

F) B) and C)
G) D) and E)

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Up-regulation


A) results in a decrease in the number of receptor sites in the target cell.
B) produces an increase in the sensitivity of the target cell to the hormone.
C) is found in target cells that maintain a constant level of receptors.
D) produces insensitivity to the hormone in the target tissue.
E) moves the receptors up on the membrane.

F) C) and D)
G) B) and E)

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Hormones act on specific tissues called _______ tissues.

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When a hormone binds to a membrane-bound receptor and activates G proteins,


A) ion channels could be opened.
B) IP3 may be activated.
C) cyclic AMP production may be increased.
D) DAG may be activated.
E) All of the choices may occur from activated G proteins.

F) C) and E)
G) C) and D)

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Match the description with the type of receptor model. -cyclic AMP or cyclic GMP involved


A) nuclear receptor model
B) membrane-bound receptor model

C) A) and B)
D) undefined

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Which pattern of hormone secretion,exemplified by thyroid hormones,remains relatively constant over long periods of time?


A) acute hormone secretion
B) episodic hormone secretion
C) chronic hormone secretion
D) long-term hormone secretion

E) All of the above
F) A) and D)

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What type of chemical messenger stimulates the cell that originally secreted it?


A) paracrine
B) neurotransmitter
C) autocrine
D) endocrine

E) B) and C)
F) All of the above

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Match the description with the type of receptor model. -used by most lipid-soluble hormones


A) nuclear receptor model
B) membrane-bound receptor model

C) A) and B)
D) undefined

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Match the chemical signal with the appropriate description. -autocrine


A) chemicals produced by neurons that function as hormones
B) chemicals that act locally on nearby cells
C) chemical secreted by presynaptic terminal
D) influences same cell type from which it is secreted
E) chemical secreted into blood by specialized cells; travels some distance to target tissues

F) C) and E)
G) B) and C)

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_______ chemical signals are released by cells and affect other cell types locally without being transported in blood.

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Match the chemical signal with the appropriate description. -neuropeptide


A) chemicals produced by neurons that function as hormones
B) chemicals that act locally on nearby cells
C) chemical secreted by presynaptic terminal
D) influences same cell type from which it is secreted
E) chemical secreted into blood by specialized cells; travels some distance to target tissues

F) B) and C)
G) A) and E)

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In some forms of diabetes,an insensitivity to insulin seems to be present.This insensitivity could be the result of


A) up-regulation.
B) over-regulation.
C) down-regulation.
D) a lack of regulation.
E) modulation.

F) D) and E)
G) A) and B)

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