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What is the area where marrow is located?


A) endosteum
B) Sharpey fibers
C) periosteum
D) medullary cavity
E) growth plate

F) A) and D)
G) B) and D)

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It is possible to determine if a child's long bone is growing by examining a radiograph of the


A) diaphysis.
B) medullary cavity.
C) epiphyseal plate.
D) articular cartilage.

E) B) and C)
F) A) and C)

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Intramembranous ossification


A) occurs when osteoblasts invade the spaces left by dying cartilage cells.
B) forms the bones of the roof of the skull.
C) occurs on the outer surface of the membrane.
D) is the process that produces most of the skeletal system.
E) occurs when bones develop from cartilage models.

F) All of the above
G) A) and D)

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The proportion of collagen to hydroxyapatite in bone determines the


A) thickness of the bone.
B) strength of the bone.
C) growth rate of bone.
D) ability of the bone to heal.
E) length of the bone.

F) A) and B)
G) None of the above

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Which of the following is correctly matched?


A) periosteum - lines the medullary cavity
B) osteoblasts - break down bone tissue
C) osteoclasts - responsible for reabsorption
D) endosteum - lines central canal of the osteon
E) osteocytes - function in bone remodeling

F) A) and B)
G) A) and C)

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True or false: The application of small electrical charges to broken bones are sometimes used to enhance healing.

A) True
B) False

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Which of the following is associated with osteoclast reabsorption of bone?


A) Osteoblasts form collagen and proteoglycans.
B) Blood calcium is decreased.
C) Ca2+ is actively transported from blood to bone matrix.
D) Hydrogen ions form an acid environment in bone matrix.
E) The protein components of bone matrix are synthesized.

F) C) and D)
G) None of the above

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Osteomalacia is


A) a disease in adults characterized by softening of bones resulting from calcium depletion.
B) bone inflammation that often results from bacterial infection.
C) a disease in children characterized by soft,bowed,and swollen bones.
D) a disease in adults,especially women,characterized by a reduced amount of bone matrix.
E) a group of genetic disorders producing very brittle bones that are easily fractured; occurs because of insufficient collagen development.

F) C) and E)
G) A) and B)

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True or false: The two types of bone development formation include endochondral and endosteal bone.

A) True
B) False

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What chemical stimulates interstitial cartilage and appositional bone growth?


A) sex hormones
B) growth hormone
C) calcitonin
D) parathyroid hormone
E) vitamin D

F) A) and E)
G) B) and E)

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Which type of bone cells have ruffled borders and secrete acids?


A) osteoblasts
B) osteochondral progenitor cell
C) osteoclasts
D) osteocytes

E) B) and C)
F) All of the above

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When a fracture begins to heal,one type of bone cell moves into the fracture site and tears down the damaged bone tissue.Which of the following does this?


A) osteoblasts
B) osteocytes
C) osteoclasts
D) osteons
E) matrix cells

F) A) and B)
G) None of the above

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Which type of bone cells combine hydroxyapatite and collagen to form extracellular bone matrix?


A) osteochondral progenitor cell
B) osteoblasts
C) osteocytes
D) osteoclasts

E) A) and B)
F) None of the above

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Which of the following statements about bone remodeling and repair is correct?


A) Bone remodeling involves removal of old bone by osteoblasts.
B) The rate of bone remodeling increases in the elderly.
C) Exposure of a bone to increased mechanical stress can lead to bone remodeling.
D) Bone remodeling does not involve the activity of the osteoclasts and the osteoblasts.
E) As a long bone increases in diameter,the size of the marrow cavity decreases.

F) A) and B)
G) A) and D)

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Ossification that involves replacing cartilage with bone is


A) interstitial.
B) endochondral.
C) intramembranous.
D) osteomalacia.
E) appositional.

F) A) and D)
G) A) and C)

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Canaliculi are found in this type of bone tissue.


A) compact bone
B) both spongy and compact
C) spongy bone

D) All of the above
E) None of the above

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The collar that forms around the opposing ends of bone fragments is called a(n)


A) osteon.
B) epiphysis.
C) hematoma.
D) internal callus.
E) external callus.

F) A) and C)
G) A) and D)

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In which of the following locations in a growing bone would the greatest osteoclast activity be found?


A) articular cartilage
B) perichondrium
C) epiphyseal plate
D) epiphysis
E) medullary cavity

F) A) and B)
G) A) and C)

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What type of tissue covers the ends of long bones?


A) articular cartilage
B) fibrocartilage
C) cancellous bone
D) elastic cartilage
E) periosteum

F) A) and B)
G) C) and E)

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The process of ______ is important to change shapes of bones,adjust to bone stress,replace old bone matrix and to facilitate repair of broken bone.


A) endochondral ossification
B) appositional bone growth
C) bone remodeling
D) intramembranous ossification

E) None of the above
F) A) and D)

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