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Which of the following statements concerning the spleen is true?


A) Splenic arteries enter the organ at the periarterial sheath.
B) The spleen can act as a blood reservoir.
C) The white pulp is associated with the venous supply.
D) The red pulp has trabeculae.
E) Humans can not survive without a spleen.

F) A) and B)
G) None of the above

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The immunoglobulin that is often the first antibody produced in response to an antigen is


A) IgD.
B) IgA.
C) IgM.
D) IgE.
E) IgG.

F) A) and D)
G) A) and E)

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Interferon production is stimulated by


A) a viral infection.
B) the complement cascade.
C) antigen-presenting cells.
D) degranulation of basophils.
E) inflammation.

F) All of the above
G) A) and D)

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If you receive an immunization for hepatitis B and produce antibodies against the hepatitis B virus, you have developed what type of adaptive immunity?


A) active natural immunity
B) active artificial immunity
C) passive natural immunity
D) passive artificial immunity
E) active passive immunity

F) C) and D)
G) A) and D)

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Active natural immunity occurs when


A) antibodies pass from a pregnant mother to her fetus.
B) antibodies are injected into a host.
C) an individual develops a disease.
D) a person is vaccinated.
E) antibodies are passed in breast milk.

F) B) and D)
G) D) and E)

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MHC class II molecules are found on


A) neutrophils, monocytes, and macrophages.
B) dendritic cells, B cells, and helper T cells.
C) monocytes, helper T cells, and neutrophils.
D) B cells, macrophages, and dendritic cells.
E) B cells, C cells and D cells.

F) A) and E)
G) A) and C)

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Which of the following is correctly matched?


A) IgA - found in saliva and tears
B) IgD - can cross the placenta
C) IgG - first to challenge the antigen
D) IgM - antigen-binding receptor on B cells
E) IgE - transfusion reactions

F) A) and E)
G) B) and D)

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Several research groups are working on vaccines that will be effective against the AIDS virus. When a successful vaccine is produced, it is likely to be injected to produce


A) active natural immunity.
B) active artificial immunity.
C) passive natural immunity.
D) passive artificial immunity.
E) active passive immunity.

F) All of the above
G) A) and E)

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Match the term with the appropriate description. -prostaglandins


A) lipids that cause smooth muscle relaxation and vasodilation
B) lymph nodules aggregated in the small intestinal wall
C) rounded epithelial structures found in the medulla of thymus
D) areas of a lymph node where lymphocytes divide
E) a chemical released from mast cells that causes vasodilation

F) A) and E)
G) B) and C)

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Tolerance is a state of


A) hypersensitivity.
B) transplant rejection.
C) unresponsiveness to antigens.
D) responding to self-antigens.
E) non-recognition of antigens.

F) B) and E)
G) None of the above

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Which of the following is NOT a mechanism of complement action?


A) produces cytokines
B) opsonization
C) attracts other immune cells to the site of infection
D) forms a MAC that leads to cell lysis

E) C) and D)
F) B) and D)

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B-cells


A) are a subset of T cells.
B) when activated become plasma cells and produce antibodies.
C) are responsible for forming all the body's memory cells.
D) suppress the activity of T cells.
E) mature in the thymus.

F) A) and D)
G) B) and C)

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Frequently, several different signals or molecules are needed in order to produce an immune response by a B cell or T cell. The second signal in this process is called


A) opsonization.
B) copresentation.
C) complement activation.
D) antigen processing.
E) costimulation.

F) B) and D)
G) B) and C)

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Natural Killer (NK) cells


A) a type of macrophage.
B) are a type of plasma cell.
C) secrete enzymes that kill tumor or virus-infected cells.
D) are derived from B cells.
E) promote inflammation.

F) C) and D)
G) B) and E)

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Lymphocytes with a CD8 glycoprotein on their surface are called ______ cells and lymphocytes with a CD4 glycoprotein on their surface are called ______ cells.


A) cytotoxic T; B
B) B; cytotoxic T
C) B; helper T
D) helper T; cytotoxic T
E) cytotoxic T; helper

F) B) and C)
G) A) and E)

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Match the appropriate characteristic with the type of immunity. -provide protection against extracellular antigens


A) innate immunity
B) antibody-mediated immunity
C) cell-mediated immunity
D) both antibody and cell-mediated immunity
E) innate immunity, antibody-mediated immunity and cell-mediated immunity

F) B) and E)
G) B) and D)

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Match the type of cell with its function. -natural killer cell


A) first cell to enter infected tissue
B) will become macrophage in tissue
C) lyses tumor and virus-infected cells
D) cell that increases in number during a parasitic infection
E) nonmotile cells in connective tissue that promote inflammation

F) A) and C)
G) A) and E)

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Bean-shaped lymphatic organs found along lymphatic vessels are called


A) lymph nodes.
B) medullary cords.
C) cisterna chyli.
D) trabeculae.
E) lymph nodules.

F) C) and D)
G) B) and C)

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Match the term with the appropriate description. -thymic corpuscles


A) lipids that cause smooth muscle relaxation and vasodilation
B) lymph nodules aggregated in the small intestinal wall
C) rounded epithelial structures found in the medulla of thymus
D) areas of a lymph node where lymphocytes divide
E) a chemical released from mast cells that causes vasodilation

F) A) and C)
G) A) and B)

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Interferon


A) directly attacks viruses.
B) protects cells that have been invaded by viruses.
C) increases vascular permeability.
D) is not produced by most cells.
E) is a protein that interferes with virus production and infection.

F) B) and E)
G) C) and E)

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