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This figure illustrates bone growth in length at the Epiphyseal Plate. What is zone "E"?


A) zone of resting cartilage
B) zone of proliferation
C) zone of calcification
D) zone of hypertrophy
E) bone of diaphysis

F) A) and C)
G) A) and E)

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Osteomyelitis is


A) a disease in adults, especially women, characterized by a reduced amount of bone matrix.
B) a disease in adults characterized by softening of bones resulting from calcium depletion.
C) a group of genetic disorders producing very brittle bones that are easily fractured; occurs because of insufficient collagen development.
D) a disease in children characterized by soft, bowed, and swollen bones.
E) bone inflammation that often results from bacterial infection.

F) B) and E)
G) A) and D)

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Sally has elevated levels of blood calcium. What chemical would you expect to find in high levels in response to this condition?


A) sex hormones
B) parathyroid hormone
C) growth hormone
D) calcitonin
E) vitamin D

F) All of the above
G) C) and D)

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The two types of bone development formation include endochondral and endosteal bone.

A) True
B) False

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The parietal bone is formed by ___________


A) endochondral ossification
B) intramembranous ossification

C) A) and B)
D) undefined

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The epiphysis of the clavicle are formed by ___________


A) endochondral ossification
B) intramembranous ossification

C) A) and B)
D) undefined

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A boy grew rapidly and reached a height of 6'2" by the time he was 13. He had normal body proportions and sexual development was only slightly retarded. Which of the following caused his condition?


A) elevated vitamin D synthesis
B) hypersecretion of growth hormone
C) hypersecretion of testosterone
D) hyposecretion of growth hormone
E) an adrenal tumor that secretes androgens

F) C) and D)
G) A) and B)

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The flat bones of the skull develop from


A) fibrous connective tissue.
B) fibrocartilage.
C) compact bone.
D) hyaline cartilage.
E) areolar tissue.

F) C) and E)
G) A) and B)

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The connective tissue sheath of cartilage is called the


A) ligamentous cord.
B) lacuna.
C) chondrocyte.
D) matrix.
E) perichondrium.

F) All of the above
G) None of the above

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You would look for concentric lamellae


A) as components of the cartilage.
B) in between osteons.
C) around the central canal of an osteon.
D) on the outer surface of compact bone tissues.
E) in the bone marrow.

F) A) and B)
G) A) and C)

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Arrange the following events in endochondral ossification in proper sequence: (1) Cartilage matrix is calcified and chondrocytes die. (2) Chondrocytes hypertrophy. (3) Cartilage model is formed. (4) Osteoblasts deposit bone on the surface of the calcified cartilage called the primary ossification center. (5) Blood vessels from the periosteum invade calcified cartilage bringing in osteoblasts and osteoclasts.


A) 3, 2, 1, 5, 4
B) 3, 5, 2, 4, 1
C) 3, 2, 5, 1, 4
D) 1, 3, 4, 5, 2
E) 3, 2, 5, 4, 1

F) A) and D)
G) D) and E)

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A connective tissue sheath around cartilage is the


A) periosteum.
B) ligament.
C) endosteum.
D) epiphyseal line.
E) perichondrium.

F) C) and D)
G) B) and D)

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Rickets is


A) bone inflammation that often results from bacterial infection.
B) a group of genetic disorders producing very brittle bones that are easily fractured; occurs because of insufficient collagen development.
C) a disease in children characterized by soft, bowed, and swollen bones.
D) a disease in adults, especially women, characterized by a reduced amount of bone matrix.
E) a disease in adults characterized by softening of bones resulting from calcium depletion.

F) B) and E)
G) None of the above

Correct Answer

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Which type of bone cells are large cells that form from fusion of monocytes?


A) osteochondral progenitor cell
B) osteocytes
C) osteoblasts
D) osteoclasts

E) B) and D)
F) A) and B)

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This figure illustrates bone growth in length at the Epiphyseal Plate. What is zone "C"?


A) zone of resting cartilage
B) zone of proliferation
C) zone of calcification
D) bone of diaphysis
E) zone of hypertrophy

F) A) and E)
G) A) and C)

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Ossification that involves replacing cartilage with bone is


A) interstitial.
B) endochondral.
C) intramembranous.
D) osteomalacia.
E) appositional.

F) A) and D)
G) B) and C)

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What is the area where marrow is located?


A) endosteum
B) Sharpey fibers
C) periosteum
D) medullary cavity
E) growth plate

F) None of the above
G) A) and D)

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Which of the following is NOT an effect of parathyroid hormone (PTH) ?


A) increased Ca2+ uptake by the small intestine
B) increased vitamin D formation in the kidneys
C) increased Ca2+ reabsorption by the kidneys
D) decreased Ca2+ loss by the kidneys
E) All of these are effects of PTH.

F) A) and D)
G) B) and E)

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Twelve-year old Madeline has not yet experienced a bone growth spurt, meaning she is not yet producing which particular chemicals necessary for this to occur?


A) calcitonin
B) sex hormones
C) parathyroid hormone
D) vitamin D
E) growth hormone

F) C) and D)
G) D) and E)

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If an X-ray shows a black area in the region of the epiphyseal plate,


A) the bone is fractured.
B) the epiphyseal plate has not completely ossified.
C) growth of the bone is complete.
D) the cartilage is absent.
E) marrow is forming in the cancellous bone.

F) A) and B)
G) A) and E)

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